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Amaryl (Glimepiride) clinical results:centerwatch:"Clinical research supports the recommendation that Amaryl be used as a monotherapy or in combination with insulin, a unique distinction among members of the sulfonylurea class of diabetes drugs. Amaryl provided highly effective glucose control with a once daily dosing schedule, which helped many type II diabetes subjects achieve 24-hour glucose control, without putting subjects at undue risk for low blood sugar, a complication of overly rigorous control. Highly effective glucose control was observed in a range of subjects including obesity and hypertension--and in traditional at risk populations such as Hispanics and African Americans" http://www.centerwatch.com/patient/drugs/dru11.html Amaryl (Glimepiride) for type II diabetes:pslgroup:"Amaryl is indicated as an adjunct to diet and exercise to lower blood glucose in people with type II diabetes whose blood glucose cannot be controlled by diet and exercise alone. Amaryl works primarily by increasing insulin secretion and lowering blood glucose concentration without putting patients at undue risk for low blood sugar. Type II diabetes, or non-insulin-dependent diabetes mellitus (NIDDM), is the more prevalent form of the disease and accounts for more than 90 percent of all cases. It occurs when the body does not produce enough insulin to control glucose levels and excess sugar in the blood occurs. Of the 8 million people diagnosed with diabetes, nearly 7.5 million have type II diabetes, and most of them require oral medication alone or in combination with insulin to keep blood sugar levels under control. " http://www.pslgroup.com/dg/7646.htm Amaryl (Glimepiride); How it works:virtualdrugstore:"Glimepiride or Amaryl stimulates the secretion of insulin by the pancreas and may as well increase tissue sensitivity to insulin. The increased level of insulin metabolises blood sugar or glucose, thus reducing the hyperglycemia of diabetes. Because Glimepiride or Amaryl's effects are on insulin and insulin secretion by the body, the pancreas must still be functioning. This means Glimepiride or Amaryl is suitable for non insulin dependent diabetes (NIDD). Glimepiride or Amaryl's actions are similar to another drug used for diabetes - glyburide" http://www.virtualdrugstore.com/diabetes/glimepiride.html Amaryl (Glimepiride) special warnings:gettingwell.com:"It's possible that drugs such as Amaryl may lead to more heart problems than diet treatment alone, or treatment with diet and insulin. If you have a heart condition, you may want to discuss this with your doctor. When taking Amaryl, you should check your blood and urine regularly for abnormally high sugar (glucose) levels. The effectiveness of any oral antidiabetic, including Amaryl, may decrease with time. This may occur because of either a diminished responsiveness to the medication or a worsening of the diabetes. Even people with well-controlled diabetes may find that stress such as injury, infection, surgery, or fever triggers a loss of control. If this happens, your doctor may recommend that you add insulin to your treatment with Amaryl or that you temporarily stop taking Amaryl and use insulin instead." http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/ama1016.shtml Amaryl (Glimepiride) warning:The West Georgia Center for Metabolic Disorders and The Midwest Diabetes Care Center:"The unusual double-egg shape, colors, and the size of Amaryl pills are almost identical to the shape, colors, and size of a standard brand of thyroid hormone, Levoxyl (manufactured by Daniels Pharmaceuticals). If the patient is on both Amaryl and Levoxyl, or if the patient is in a setting such as a hospital or nursing home where both pills are available in containers located nearby to each other, EXTREME CAUTION must be taken that the medications are not mistaken for each other!" http://www.vghks.gov.tw/meta/hclam/amaryl.htm Amaryl (Glimepiride) contraindications and overdose:rxlist:"Overdosage of sulfonylureas, including glimepiride, can produce hypoglycemia. Mild hypoglycemic symptoms without loss of consciousness or neurologic findings should be treated aggressively with oral glucose and adjustments in drug dosage and/or meal patterns. Close monitoring should continue until the physician is assured that the patient is out of danger. Severe hypoglycemic reactions with coma, seizure, or other neurological impairment occur infrequently, but constitute medical emergencies requiring immediate hospitalization. If hypoglycemic coma is diagnosed or suspected, the patient should be given a rapid intravenous injection of concentrated (50%) glucose solution. Glimepiride is Contraindicated in Patients with: 1. Known hypersensitivity to the drug. 2. Diabetic ketoacidosis, with or without coma. This condition should be treated with insulin." http://www.rxlist.com/cgi/generic/glimepiride_od.htm Amaryl (Glimepiride) mechanism of action:drugdigest:"Glimepiride lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must be capable of producing insulin for this medication to work. Glimepiride is used with diet and exercise to treat Type 2 (noninsulin-dependent) diabetes (formerly "adult-onset"). Glimepiride may be used with or without insulin. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information" http://www.drugdigest.org/DD/DVH/MOA/0,8635,298|Amaryl,00.html Search Nursing Diabetics http://www.nursingdiabetics.com/A-Z_list/ ******************************************************
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