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Clinical treatment of atherosclerosis:Center for Research, Prevention and Treatment of Atherosclerosis:"Our main clinical activities include:
1) Treatment of patients with lipid disorders, atherosclerosis or its complications and initiation of clinical preventive programs.
2) Clinical, biochemical and molecular diagnosis of dyslipidemias, Cardiomyopathies, and rare metabolic disorders.
3) Implementation of current knowledge, national and international guidelines for the prevention and treatment of atherosclerosis.
4) Development of new diagnostic tools and treatment modalities based on the results of basic and clinical research."
The Department of Medicine
Hadassah Hebrew University Hospital
Tel: 02 - 6776449
Fax: 02 - 6777394
http://www.hadassah.org.il/departments/medicine/c1.htm

Management Strategies in the Treatment of Atherosclerosis:answeb.net:"This site offers video feeds and slide shows in the following catagories: Strategies for Approaching the Patient with Low HDL, CV Risk in Diabetics, Ensuring Optimal Treatment of Risk Factors in CHD Patients, Evidence Based Medicine. To have an access to the interventions, you need to install the Netshow plug-in and/or the Real G2 plug-in. Downloads are available on the page."
http://www.answeb.net/ecor/

Lecithin Cholesterol Acyltransferase (LCAT) for the Treatment of Atherosclerosis and LCAT Deficiency:bioinfo.com:"SUMMARY: In humans, the development of atherosclerosis is positively and inversely correlated with the plasma levels of low density lipoproteins (LDL) and high density lipoproteins (HDL) respectively. LCAT, the major enzyme involved in the esterification of free cholesterol present in circulating plasma lipoproteins, is a major determinant of plasma HDL concentrations. Recent studies have established that transgenic rabbits overexpressing human LCAT have 6-7 fold higher plasma HDL levels than control, non-transgenic siblings. In addition, LCAT transgenic rabbits have reduced plasma concentrations of the atherogenic LDL and apoB-containing lipoproteins. This lipoprotein phenotype characterized by elevated plasma HDL and reduced LDL levels leads to marked protection against the development of diet-induced atherosclerosis in LCAT transgenic rabbits compared to control animals."
http://www.bioinfo.com/nihfr0906.html

Risk Factor Reduction in the Treatment of Atherosclerosis:clevelandclinic:"Risk factor modification It has been clearly shown that modification of existing cardiovascular risk factors can have numerous beneficial effects. The incidence of heart attack and stroke can be diminished considerably by controlling risk factors. A number of studies have now been published demonstrating that control of risk factors (specifically lowering cholesterol levels) can help prevent the progression of atherosclerosis and even cause regression of atherosclerosis that is already present. Cigarette smoking Discontinuation of cigarette smoking is perhaps the most important risk factor in the development of atherosclerosis. Smoking accounts for at least 410,000 deaths per year and is a major cause of heart attacks, stroke and circulatory problems of the leg arteries. Stopping smoking is the single most important step you can take to improve overall cardiovascular risk."
http://www.clevelandclinic.org/health/health-info/docs/0800/0825.asp?index=4561

New treatment for atherosclerosis:medhelp.org:"Research into the growth factors that promote new blood vessel formation has seen some tremendous advances over the past decade. Several groups are working in this arena, including Dr. Jeffrey Isner's group at St. Elizabeth's Hospital in Boston, and the Cornell group in Ithaca, NY (Dr. Ronald Crystal, Cornell Medical Center). This technique is highly investigational. However, some promising results have been demonstrated in patients suffering from peripheral vascular disease (limb ischemia) with improvements in select measures of blood flow noted over weeks to months of therapy. Efforts to test this technique in coronary artery disease are only now beginning. Theoretically, this might be a helpful adjunct to traditional medical and surgical therapy for coronary disease. It might be particularly helpful for patients who are not candidates for traditional bypass surgery or angioplasty due to severe diffuse disease in the coronary arteries, with vessels that are too small to bypass or balloon dilate. The risks of the procedure are not clearly defined. Some complications include hemangiomas(proliferation of small blood vessels) on the skin downstream from where the growth factor was injected in the legs of some patients. More study will have to be done to better understand these risks"
http://www.medhelp.org/forums/cardio/archive/484.html

HOC Treatment Protocols - Atherosclerosis:hochealth.com:"Atherosclerosis is a condition in which arteries become lined with plaques made of fatty material. The blood vessel narrows, and less blood flows through. This prevents nutrients and oxygen from reaching tissues and organs in the body, causing various health conditions and disorders. High blood pressure, intermittent claudication, angina, heart attack, and stroke can all result from atherosclerosis. Unfortunately, symptoms of atherosclerosis only become apparent after 90% of the vessel diameter is blocked. When an artery becomes narrow enough, even a very small blood clot may cause a complete obstruction. Heart attacks occur when a vessel in the heart is occluded, and strokes occur when a vessel in the brain is occluded."
http://www.hochealth.com/conditions/atherosclerosis.html

Millimeter-Wave and Microwave Treatment of Atherosclerosis:nasatech.com:"Millimeter-wave/microwave ablation (essentially, heating by use of millimeter-wave and microwave electromagnetic radiation) has been proposed as a means of treating atherosclerotic lesions. Computational simulations have shown that by controlling and customizing temperature profiles in millimeter-wave/microwave ablation, it should be possible to (1) treat atherosclerosis or coronary thrombosis without (2) incurring the distensions and injuries to arterial walls and epithelial walls that are common to current invasive treatments, while (3) possibly reducing post-treatment inflammation and even restenosis. Although millimeter-wave/microwave ablation has yet to be proved in tests on live animals, it offers the potential to significantly advance the state of the art. Indeed, after further testing, millimeter-wave/microwave ablation might be used by cardiologists during balloon angioplasty replacement procedures (PTCAs) or coronary catheterizations. Because it is expected to be safer and more effective than traditional methods, millimeter-wave/microwave ablation could soon supplement or even supplant today's treatment choices."
http://www.nasatech.com/Briefs/Feb02/MSC22724.html

Update on the Treatment of Atherosclerosis:mednet.ca:"Accumulating evidence points to the vulnerability of atherosclerotic plaque as the key factor in the evolution of myocardial infarction and other acute coronary syndromes. Lipid-lowering therapy retains an essential risk-reducing role, and the scope of benefit appears to involve factors such as cholesterol particle size, endothelial function and thrombus formation. The evolving concept of the vulnerable plaque offers a persuasive explanation for the observation that reduced risk often occurs in the presence of minimal angiographic change in atherosclerotic lesions and in the presence of near-normal cholesterol levels. The concept also is consistent with the recently developed knowledge that most myocardial infarctions occur in patients who do not have flow-limiting coronary atherosclerotic stenoses. Despite abundant evidence of the beneficial effects of lipid-lowering therapy, a majority of patients who might benefit from the therapy still do not receive it"
http://www.mednet.ca/html/ppcardio30.htm

Treatment for atherosclerosis:stanfordhospital.com:"Specific treatment for atherosclerosis will be determined by your physician based on: your age, overall health, and medical history,extent of the disease location of the blockage, signs and symptoms, your tolerance for specific medications, procedures, or therapies, expectations for the course of the disease, your opinion or preference, Treatment may include: lifestyle modifications (to control risk factors, including regular exercise, proper nutrition, and smoking cessation) coronary angioplasty - with this procedure, a catheter is used to create a bigger opening in the vessel to increase blood flow. Although angioplasty is performed in other blood vessels, percutaneous transluminal coronary angioplasty (PTCA) refers to angioplasty in the coronary arteries to permit more blood flow into the heart. There are several types of PTCA procedures, including the following:"
http://www.stanfordhospital.com/healthLib/atoz/cardiac/athero.html

Treatment of atheroslerosis many include many options:University of Maryland Medicine:"Treatment may include: lifestyle modifications to control risk factors, including regular exercise, proper nutrition, and smoking cessation coronary angioplasty - with this procedure, a catheter is used to create a bigger opening in the vessel to increase blood flow. Although angioplasty is performed in other blood vessels, Percutaneous Transluminal Coronary Angioplasty (PTCA) refers to angioplasty in the coronary arteries to permit more blood flow into the heart. There are several types of PTCA procedures, including: balloon angioplasty - a small balloon is inflated inside the blocked artery to open the blocked area. atherectomy - the blocked area inside the artery is "shaved" away by a tiny device on the end of a catheter. laser angioplasty - a laser used to "vaporize" the blockage in the artery. coronary artery stent - a tiny coil is expanded inside the blocked artery to open the blocked area and is left in place to keep the artery open"
http://www.umm.edu/cardiac/athero.htm



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Last updated by Andrew Lopez, RN on Wednesday, September 29, 2010


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