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Diabeta (Glyburide) what is it?:UMHS:"Diabeta (die-uh-BET-ah) is a nonaddictive prescription medicine widely used to treat Type 2, noninsulin dependent diabetes. Diabeta is usually prescribed in tablet form. It works by stimulating the body to make more insulin and by helping insulin to work more efficiently. Sugar must be able to get inside the body's cells to be used for energy, which keeps blood sugar levels under control. Diabeta helps keep this delicate balance under control, although it may take 3 to 4 hours before the effects are noticed. Follow your doctor's dosage recommendations to the letter and if you miss a dose, take as soon as possible unless close to the next scheduled dose. Do not double the dosage to compensate, just take the next regular dose as scheduled." http://www.med.umich.edu/1libr/prescrpt/diabet01.htm Diabeta (Glyburide) why is it prescribed?:gettingwell.com:"Micronase is an oral antidiabetic medication used to treat type 2 diabetes, the kind that occurs when the body either does not make enough insulin or fails to use insulin properly. Insulin transfers sugar from the bloodstream to the body's cells, where it is then used for energy. There are two forms of diabetes: type 1 and type 2. Type 1 diabetes results from a complete shutdown of normal insulin production and usually requires insulin injections for life, while type 2 diabetes can usually be treated by dietary changes, exercise, and/or oral antidiabetic medications such as Micronase. This medication controls diabetes by stimulating the pancreas to produce more insulin and by helping insulin to work better. Type 2 diabetics may need insulin injections, sometimes only temporarily during stressful periods such as illness, or on a long-term basis if an oral antidiabetic medication fails to control blood sugar. Micronase can be used alone or along with a drug called metformin (Glucophage) if diet plus either drug alone fails to control sugar levels" http://www.gettingwell.com/drug_info/rxdrugprofiles/drugs/MIC1264.shtml Diabeta (Glyburide) clinical pharmacology:druginfonet:"Glyburide appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which glyburide lowers blood glucose during long-term administration has not been clearly established. With chronic administration in Type II diabetic patients, the blood glucose lowering effect persists despite a gradual decline in the insulin secretory response to the drug. Extrapancreatic effects may play a part in the mechanism of action of oral sulfonylurea hypoglycemic drugs. In addition to its blood glucose lowering actions, glyburide produces a mile diuresis by enhancement of renal free water clearance. Clinical experience to date indicates an extremely low incidence of disulfiram-like reactions in patients while taking glyburide" http://www.druginfonet.com/glyburid.htm#CLINICAL%20PHARMACOLOGY Diabeta (Glyburide) geriatric drug review:agenet:"This agent is a longer acting second-generation oral hypoglycemic agent. It is commonly used in the elderly with good glucose lowering effect. However, it should be used with caution in the elderly due to the reduced kidney function commonly experienced by older adults. Reduced kidney function may lead to an increased risk of developing severe low blood sugar reactions (hypoglycemia). We recommend using the generic product since it is equivalent in effect and safety, yet less expensive than the brand name" http://www.agenet.agenet.com/Category_Pages/document_display.asp?Id=201& Diabeta (Glyburide) drug class and mechanism:focusondiabetes:"Glyburide is an oral glucose lowering-drug in a class of diabetes medicines called sulfonylureas. Glyburide lowers the sugar level by stimulating insulin secretion in the pancreas. Insulin is a hormone which lowers the blood sugar level. Approximately 90% of patients with diabetes have type 2 or non-insulin dependent diabetes mellitus. Type 2 diabetes usually occurs in adulthood, and is associated with obesity and a strong family history of the disease. Sugar (glucose) intolerance is related to impaired insulin secretion by the pancreas and resistance to insulin at the cell level." http://www.focusondiabetes.com/script/main/art.asp?articlekey=755&rd=1 Diabeta (Glyburide) side effects:ElizJack@IntNet.Net :"Headache, stomach upset, loss of appetite, nausea, diarrhea or vomiting may occur as your body adjusts to the medication. Inform your doctor if you develop itchy skin, dark urine, fever, sore throat, swelling of the hands or feet or unusual bleeding or bruising while taking this medication. This medication can cause low blood sugar (hypoglycemia). The symptoms include chills, cold sweat, shaking, rapid heart rate, weakness, headache, fainting. If you experience these symptoms, eat a quick source of sugar such as table sugar, orange juice, honey, non-diet soda. Tell your doctor about the reaction. To help prevent hypoglycemia, eat meals on a regular schedule and do not skip meals. Symptoms of high blood sugar (hyperglycemia) include confusion, drowsiness, flushing, rapid breathing, or fruity breath odor. If these symptoms occur, contact your doctor. This medication can increase sensitivity to sunlight." http://members.aol.com/lowcarbs/diabetes/meds/gly.htm Diabeta (Glyburide) advanced consumer information:drugs.com:"Sulfonylurea antidiabetic agents (also known as sulfonylureas) are used to treat a certain type of diabetes mellitus (sugar diabetes) called type 2 diabetes. When you have type 2 diabetes, insulin is still being produced by your pancreas. Sometimes the amount of insulin you produce may not be enough or your body may not be using it properly and you may still need more. Sulfonylureas work by causing your pancreas to release more insulin into the blood stream. All of the cells in your body need insulin to help turn the food you eat into energy. This is done by using sugar (or glucose) in the blood as quick energy. Or the sugar may be stored in the form of fats, sugars, and proteins for use later, such as for energy between meals." http://www.drugs.com/xq/cfm/pageID_0/htm_202742/type_cons/bn_DiaBeta/micr_medex/qx/index.htm Diabeta (Glyburide) What are the precautions when taking this medicine? :healthtrust:"Wear disease medical alert identification for diabetes. If you are 80 years of age or older, you may be more sensitive to low blood sugars. Avoid alcohol intake (includes wine, beer, and liquor). Keep hard candies, liquid glucose, or milk on hand for low blood sugars. Do not drive if blood sugar has been low. There is a greater risk of an accident. Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, throat; or any other symptoms involved. Tell healthcare provider if you are pregnant or plan on getting pregnant. Tell healthcare provider if you are breast-feeding." http://www.healthtrust.com/intmed/Access2Cons2/ConsDrugs/Glyburidecd.shtml Diabeta (Glyburide) special precautions:health central:"DiaBeta must not be taken by people who are allergic to sulfa drugs. Your doctor will need frequent blood tests to adjust the dose of DiaBeta when you begin taking it. Illness or a change in your exercise program may also make it necessary to adjust the dose later on" http://www.healthcentral.com/peoplespharmacy/PPDrugFullText_SpecPrecBrand.cfm?ID=22&brandname=DiaBeta Diabeta (Glyburide) dosage information:healthsquare:"ADULTS Usually the doctor will prescribe an initial daily dose of 2.5 to 5 milligrams. Maintenance therapy usually ranges from 1.25 to 20 milligrams daily. Daily doses greater than 20 milligrams are not recommended. In most cases, Micronase is taken once a day; however, people taking more than 10 milligrams a day may respond better to twice-a-day dosing. CHILDREN The safety and effectiveness of Micronase have not been established in children. OLDER ADULTS Older, malnourished or debilitated individuals, or those with impaired kidney and liver function, usually receive lower initial and maintenance doses to minimize the risk of low blood sugar (hypoglycemia)." http://www.healthsquare.com/newrx/mic1264.htm Search Nursing Diabetics http://www.nursingdiabetics.com/A-Z_list/ ******************************************************
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