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Treatment for diabetic ulcers

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Take care of you feet for a lifetime/ a guide for people with diabetes:intelihealth:"Tips for Proper Footwear Proper footwear is very important for preventing serious foot problems. Athletic or walking shoes made of canvas or leather are good for daily wear. They support your feet and allow them to "breathe." Never wear vinyl or plastic shoes, because they don't stretch or "breathe." When buying shoes, make sure they are comfortable from the start and have enough room for your toes. Don't buy shoes with pointed toes or high heels. They put too much pressure on your toes."
http://www.intelihealth.com/IH/ihtIH/WSIHW000/21054/24347/202762.html?d=dmtContent

Vacuum-assited closure an option for ulcers:Dermatology Times:"Chronic, difficult wounds can be treated effectively with vacuum-assisted wound closure, according to Michael J. Morykwas, Ph.D., director of research, department of plastic and reconstructive surgery, Wake Forest University, Winston-Salem, N.C. The subatmospheric pressure technique prevents chronic edema, increases localized blood flow and enhances formation of granulation tissue, making it a useful treatment option for difficult-to-treat chronic wounds such as pressure ulcers, diabetic ulcers, and venous stasis ulcers, according to Dr. Morykwas, who chaired the meeting, "Vacuum Closure and Management of Wounds, First International Conference.""
http://www.findarticles.com/cf_dls/m0UMR/10_21/66472580/p1/article.jhtml

ADA: Fragmin (Dalteparin) Injections Help Heal Diabetic Foot Ulcers:Doc's Guide:"Treatment with Fragmin® (dalteparin) promotes healing of chronic foot ulcers in diabetic patients with peripheral arterial occlusive disease, investigators reported here this week at the 62nd Scientific Sessions of the American Diabetes Association (ADA). Their results also show that the number of foot amputations required because of ulcers can be reduced by adding dalteparin to a multidisciplinary treatment regimen."
http://www.pslgroup.com/dg/215ca2.htm

Treating diabetic ulcers on the foot:The Jamaica Online Star:"Suitable dressings for the ulcer would include ENZYME DEBRI-DEMENT agents such as ELASE ointment or SOLCOSERYL cream. SUFREXAL gel is a newer topical agent which improves the blood supply locally to its area of use, lessens tissue inflammation and heightens tissue granulation (healing). It is useful in the care of ulcers."
http://www.jamaicastar.com/thestar/20020503/features/features3.html

Clinical Trials: Diabetic Foot Ulcers:Center Watch:"You may want to consider being involved in a clinical trial this site lists what trials are going on according to state. Clinical trials make it possible to treat diseases. for more about clinical trials or to view which ones are available visit centerwatch.com today."
http://www.centerwatch.com/patient/studies/cat229.html

Hyperbaric oxygen (HBO) therapy in treatment of diabetic foot ulcers. Long-term follow-up.:Pub Med:"The cause of diabetic foot ulcers is multifactorial, e.g., neuropathy and angiopathy, leading to functional disturbances in the macrocirculation and skin microcirculation. Adequate tissue oxygen tension is an essential factor in infection control and wound healing. Hyperbaric oxygen (HBO) therapy, daily sessions of oxygen breathing at 2.5-bar increased pressure in a hyperbaric chamber, has beneficial actions on wound healing including antimicrobial action, prevention of edema and stimulation of fibroblasts"
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12039 398&dopt=Abstract

:oandp.com:"Biotechnology Enhances Treatment of Diabetic Ulcers Biotechnology research has yielded three new products for the treatment of diabetic ulcers: living skin equivalents Apligraf and Dermagraft, and healing gel Regranex. Though these products are more expensive than traditional wound care bandages and ointments, manufacturers and health-care professionals note that the reduction in healing time compensates for the added cost."
http://www.oandp.com/facilities/ia/ampro/winter00/winter003.htm

Pressure relieving interventions for preventing and treating diabetic foot ulcers:Mediscope:"There is limited evidence of the effectiveness of orthotic interventions over removal of callus. There is some evidence evaluating the relative effectiveness of two types orthotic devices. There is very limited evidence of the effectiveness of therapeutic shoes. Treatment There is very limited evidence of the effectiveness of total contact casts in the treatment of diabetic foot ulcers. Overall there is a need to measure the effectiveness of the range of pressure relieving interventions for the prevention and treatment of diabetic foot ulcers as there is a small amount of poor quality research in this area."
http://www.mediscope.ch/cochrane-abstracts/ab002302.htm

"Skin equivalent" helps diabetic ulcers heal:trustmed.com:"A "human skin equivalent" that layers new skin cells over wounds can quickly heal foot ulcers in diabetics, a study shows. Seven of 10 diabetics saw their foot wounds heal completely after treatment with Apligraf, a human skin equivalent (HSE) made of layers of cells taken from circumcised foreskins."
http://www.trustmed.com.tw/news/2000/06/21/20000620017e.html

Healing of Diabetic Foot Ulcers and Pressure Ulcers With Human Skin Equivalent:American Medical association:"In diabetic ulcers and pressure ulcers of various durations, the application of HSE with the surgical principles used in a traditional skin graft is successful in producing healing. The high success rate with complete closure in these various types of wounds suggests that HSE may function as a reservoir of growth factors that also stimulate wound contraction and epithelialization. If a wound has not fully healed after 6 weeks, a second application of HSE should be used. If the wound is not healing, an occult infection is the likely cause."
http://archsurg.ama-assn.org/issues/v135n6/abs/sws9016.html



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Last updated by Andrew Lopez, RN on Wednesday, September 29, 2010


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