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Diabinese (Chlorpropamide) dosage instructions:nursespdr:"Tablets Diabetes. Adults, middle-aged clients, mild to moderate diabetes, initial: 250 mg/day as a single or divided dose; geriatric, debilitated, or malnourished, impaired renal/hepatic function, initial: 100-125 mg/day. All clients, maintenance: 100-250 mg/day as single or divided doses. Severe diabetics may require 500 mg/day; doses greater than 750 mg/day are not recommended. Note: Use the following guidelines when transferring Type 2 diabetics on insulin to chlorpropamide. If the insulin dose is 40 units or less, start with 250 mg/day of chlorpropamide; insulin may be abruptly discontinued. If the insulin dose is over 40 units, start with 250 mg/day of chlorpropamide and reduce insulin dose by 50%; further reduce as response is seen. Consider hospitalization during the transition. Neurogenic diabetes insipidus. Adults: 200-500 mg/day." http://www.nursespdr.com/members/database/ndrhtml/chlorpropamide.html Why is Diabinese (Chlorpropamide) prescribed?:medlineplus:"Chlorpropamide is used to treat type II (noninsulin-dependent) diabetes (formerly 'adult-onset'), particularly in people whose diabetes cannot be controlled by diet alone. Chlorpropamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body to use insulin efficiently. The pancreas must produce insulin for this medication to work. Chlorpropamide is not used to treat type I (insulin-dependent) diabetes (formerly 'juvenile-onset'). This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information" http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682479.html What is the most important information I should know about Diabinese (Chlorpropamide)?:health.msn.com:"Treatment with chlorpropamide may increase the risk of death from cardiovascular disease compared to treatment of diabetes with diet alone or diet plus insulin. Discuss with your doctor the risks and benefits of treatment with chlorpropamide. Know the signs and symptoms of low blood sugar (hypoglycemia), which include headache, drowsiness, weakness, dizziness, fast heartbeat, sweating, tremor, and nausea. Carry a piece of hard candy or glucose tablets with you to treat episodes of low blood sugar. Follow diet, medication, and exercise routines closely. Changing any of them can affect your blood sugar levels. Do not change your dose of chlorpropamide without first talking to your doctor. Avoid alcohol. It lowers blood sugar and may interfere with your diabetes treatment." http://content.health.msn.com/drug_article/article/4046.1560?bn=Diabinese Diabinese (Chlorpropamide) clinical pharmacology:rxlist:"Chlorpropamide appears to lower the blood glucose acutely by stimulating the release of insulin from the pancreas, an effect dependent upon functioning beta cells in the pancreatic islets. The mechanism by which chlorpropamide lowers blood glucose during the long-term administration has not been clearly established. Extra-pancreatic effects may play a proof in the mechanism of action of oral sulfonylurea hypoglycemic drugs. Chlorpropamrde may also prove effective in controlling certain patients who have experienced primary or secondary failure to other sulfonylurea agents. While chlorpropamide is a sulfonamide derivative, it is devoid of antibacterial activity. " http://www.rxlist.com/cgi/generic2/chlorpro_cp.htm Diabinese (Chlorpropamide) What side effects may occur?:healthsquare:"Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Diabinese. Side effects from Diabinese are rare and seldom require discontinuation of the medication. More common side effects include: Diarrhea, hunger, itching, loss of appetite, nausea, stomach upset, vomiting Less common or rare side effects may include: Anemia and other blood disorders, hives, inflammation of the rectum and colon, sensitivity to light, yellowing of the skin and eyes" http://www.healthsquare.com/newrx/dia1130.htm Proper Use of Diabinese (Chlorpropamide):drugs.com:"Your doctor will give you instructions about diet, exercise, how to test your blood sugar levels, and how to adjust your dose when you are sick. Diet—The daily number of calories in the meal plan should be adjusted by your doctor or a registered dietitian to help you reach and maintain a healthy body weight. In addition, regular meals and snacks are arranged to meet the energy needs of your body at different times of the day. It is very important that you follow your meal plan carefully. Exercise—Ask your doctor what kind of exercise to do, the best time to do it, and how much you should do each day. Blood tests—This is the best way to tell whether your diabetes is being controlled properly. Blood sugar testing helps you and your health care team adjust the dose of your medicine, meal plan, or exercise schedule." http://www.drugs.com/xq/cfm/pageID_0/htm_202742/type_cons/bn_Diabinese/micr_medex/qx/index.htm What are the precautions when taking Diabinese (Chlorpropamide):healthtrust:"Wear disease medical alert identification for diabetes. If you are 80 years of age or older, you may be more sensitive to low blood sugars. Avoid alcohol intake (includes wine, beer, and liquor). Can cause reactions. These reactions include flushing, headache, nausea, vomiting, racing heart or rapid heartbeats. Do not drive if blood sugar has been low. There is a greater risk of an accident. Avoid use in kidney disease. Talk with healthcare provider. Keep hard candies, liquid glucose, or milk on hand for low blood sugars. Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, throat; or any other symptoms involved. Tell healthcare provider if you are pregnant or plan on getting pregnant. Tell healthcare provider if you are breast-feeding" http://www.healthtrust.com/intmed/Access2Cons2/ConsDrugs/Chlorpropamidecd.shtml What should you monitor while taking Diabinese (Chlorpropamide):usadrug:"Check blood sugar as ordered by healthcare provider. Call if glucose is less than 80 mg/dL or greater than 250 mg/dL. Bring results to follow-up visits. Watch for low blood sugar. This can cause anger, shaking, rapid heartbeats, confusion, sweating. Watch for high blood sugar. Causes many trips to the bathroom, thirst, and weight loss. Check blood work. Talk with healthcare provider. Follow diet plan and exercise program as recommended by healthcare provider. Have a yearly eye exam and visit to the foot doctor" http://www.usadrug.com/IMCAccess/ConsDrugs/Chlorpropamidecd.shtml#Monitor Diabinese (Chlorpropamide) drug interactions:ElizJack@IntNet.Net:"Inform your doctor about all the medicines you use (both prescription and nonprescription) especially if you are using "blood thinners" (Coumadin-like drugs), MAO inhibitors (e.g., furazolidone, phenelzine, selegiline, tranylcypromine), beta blockers (e.g., metoprolol, propranolol, timolol) including certain glaucoma eye medicines, aspirin-like drugs or probenecid because your dose may need to be adjusted." http://members.aol.com/lowcarbs/diabetes/meds/chlor.htm Special warnings about Diabinese (Chlorpropamide):naturalessentials:"It’s possible that drugs such as Diabinese may lead to more heart problems than diet treatment alone, or diet plus insulin. If you have a heart condition, you may want to discuss this with your doctor. If you are taking Diabinese, you should check your blood and urine periodically for the presence of abnormal sugar levels. Remember that it is important that you closely follow the diet and exercise regimen established by your doctor. Even people with well-controlled diabetes may find that stress, illness, surgery, or fever results in a loss of control. If this happens, your doctor may recommend that Diabinese be discontinued temporarily and insulin used instead." http://www.naturalessentials.com/diabinese.htm Search Nursing Diabetics http://www.nursingdiabetics.com/A-Z_list/ ******************************************************
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