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Drug interactions with Glyset (Miglitol):virtualdrugstore:"With other drugs that also reduce blood sugar levels, Miglitol or Glyset has the potential to lower them too far, that is produce hypoglycemia. If hypoglycemia does occur, glucose not sucrose is needed to reverse the effect - Miglitol or Glyset will prevent the absorption of sucrose"
http://www.virtualdrugstore.com/diabetes/miglitol.html
Glyset(Miglitol) description:medlineplus:"Miglitol (MIG-le-tall)is used to treat high blood sugar levels that are caused by a type of diabetes mellitus or sugar diabetes called type 2 diabetes. Normally, after you eat, your pancreas releases insulin to help your body store excess sugar for later use. This process occurs during normal digestion of food. In type 2 diabetes, your body does not work properly to store the excess sugar and the sugar remains in your bloodstream. Having high blood sugar can lead to serious health problems in the future. Proper diet is the first step in managing type 2 diabetes but often medicines are needed to help your body. Miglitol is a medicine that slows the digestion of sugars so your body has time to store extra sugar. Sometimes another medicine called sulfonylurea can be used in combination with miglitol to help your body store more sugar."
http://www.nlm.nih.gov/medlineplus/druginfo/miglitolsystemic500231.html
Action/Kinetics associated with Glyset (Migitol):nursespdr:"Action/Kinetics: Acts by delaying digestion of ingested carbohydrates resulting in smaller rise in blood glucose levels after meals. Effect is due to reversible inhibition of membrane-bound intestinal glucoside hydrolase enzymes which hydrolyze oligosaccharides and disaccharides to glucose and other monosaccharides. Reduces levels of glycosylated hemoglobin in type II diabetes. Does not enhance insulin secretion or increase insulin sensitivity. Does not cause hypoglycemia when given in fasted state. Absorption is saturable at high doses (i.e., only 50% to 70% of 100 mg dose is absorbed while 25 mg dose is 100% absorbed). Peak levels: 2-3 hr. Drug is not metabolized and is eliminated unchanged in urine. Reduce dose in impaired renal function."
http://www.nursespdr.com/members/database/ndrhtml/miglitol.html
Glyset (Miglitol) How does it work and what are some guildlines for using it?:Joslin Diabetes Center:"Glyset slows the digestion of carbohydrates (sugars and starches) in the small intestine.
Glyset decreases peaks in blood glucose levels that occur after eating by delaying the absorption of carbohydrates into the bloodstream.
When used alone, Glyset does not cause low blood glucose (hypoglycemia). If used in combination with some diabetes medications, hypoglycemia may occur. You should take the prescribed dose of Glyset with the first bite of each main meal.
You will start with a small dose of Glyset. Your healthcare provider will gradually increase the dose as needed.
Your healthcare provider may wish to combine Glyset with another type of diabetes pill. When combined with other pills, Glyset may further improve your blood glucose control. Since Glyset works differently than other oral diabetes medications, it will not interfere with their actions."
http://www.joslin.harvard.edu/education/library/glyset.shtml
Who should not take miglitol (Glyset)?:ahealthyme:"Before taking this medication, tell your doctor if you have an inflammatory bowel disease, such as ulcerative colitis or Chron's disease; or any other disease of the stomach or intestines; ulcers of the colon;
a blockage or obstruction in your intestines; or kidney disease. You may not be able to take miglitol, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Call your doctor if you develop a fever or an infection, or if you experience a serious injury. You may require insulin for a period of time to control your blood sugar levels. Miglitol is in the FDA pregnancy category B. This means that it is not expected to harm an unborn baby. Do not take miglitol without first talking to your doctor if you are pregnant. Miglitol passes into breast milk and may affect a nursing infant. Do not take miglitol without first talking to your doctor if you are breast-feeding a baby."
http://www.ahealthyme.com/topic/topic100589975
Glyset (Miglitol) clinical results:centerwatch:"Two large studies undertaken by Bayer have shown that Glyset is particularly effective among Hispanic and African-American Type II patients. This is significant because Type II diabetes is more prevalent and is more commonly associated with complications in these subpopulations compared to Caucasian Type II patients.
Hispanics have a 300 percent higher chance of developing Type II diabetes than the general population and African-Americans are 60 percent more likely to develop Type II diabetes than Caucasians. Hispanic and African-American Type II patients have been typically under-represented in clinical trials of new diabetes therapies. The demonstration of Glyset’s efficacy and safety in these sub-populations confirm its importance as a therapeutic option for these patients."
http://www.centerwatch.com/patient/drugs/DRU232.html
glyset (Miglitol) contraindications and adverse effects:med.sc.edu:"inflammatory bowel disease, colonic ulceration or partial intestinal obstruction, predisposition to intestinal obstruction, or chronic intestinal diseases associated with disorders of digestion or absorption. GI effects: abdominal pain (12%), diarrhea (29%), flatulence (42%) [ can be minimized with slow dose titration; incidence diminishes with continued treatment] does not cause weight gain no effect on overall lipid profile but may reduce postprandial triglyceride levels possible hypoglycemia if taken in combination with sulfonylureas; if hypoglycemia occurs must use glucose tabs or gel to treat, not sucrose sources such as candy Pregnancy Category B."
http://www.med.sc.edu:1082/miglitol.htm
Precuations while taking Glyset (Miglitol):drugs.com:"Your doctor will want to check your progress at regular visits , especially during the first few weeks that you take this medicine.
It is very important to follow carefully any instructions from your health care team about: Alcohol—Drinking alcohol may cause severe low blood sugar. Discuss this with your health care team.
Other medicines—Do not take other medicines during the time you are taking miglitol unless they have been discussed with your doctor. This especially includes nonprescription medicines such as aspirin, and medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems.
Counseling—Other family members need to learn how to prevent side effects or help with side effects if they occur. Also, patients with diabetes may need special counseling about diabetes medicine dosing changes that might occur because of lifestyle changes, such as changes in exercise and diet. Furthermore, counseling on contraception and pregnancy may be needed because of the problems that can occur in patients with diabetes during pregnancy.
Travel—Keep a recent prescription and your medical history with you. Be prepared for an emergency as you would normally. Make allowances for changing time zones and keep your meal times as close as possible to your usual meal times."
http://www.drugs.com/xq/cfm/pageID_0/htm_500231/type_cons/bn_Glyset/micr_medex/qx/index.htm#SXX1621
Glyset (Miglitol) clinical pharmacology:rxlist:"In contrast to sulfonylureas, GLYSET does not enhance insulin secretion. The antihyperglycemic action of miglitol results from a reversible inhibition of membrane-bound intestinal a-glucoside hydrolase enzymes. Membrane-bound intestinal a-glucosidases hydrolyze oligosaccharides and disaccharides to glucose and other monosaccharides in the brush border of the small intestine. In diabetic patients, this enzyme inhibition results in delayed glucose absorption and lowering of postprandial hyperglycemia. Because its mechanism of action is different, the effect of GLYSET to enhance glycemic control is additive to that of sulfonylureas when used in combination. In addition, GLYSET diminishes the insulinotropic and weight-increasing effects of sulfonylureas. Miglitol has minor inhibitory activity against lactase and consequently, at the recommended doses, would not be expected to induce lactose intolerance"
http://www.rxlist.com/cgi/generic2/miglitol_cp.htm
Miglitol (Glyset)
Initiation and Follow-up Guidelines:alaska.net:"Key points Alpha-glucosidase inhibitor ("starch blocker"). Decreases post-prandial rise in blood sugar.
No hypoglycemia if used in monotherapy. May use with sulfonylureas, insulin, or metformin. Safe for hepatically-impaired conditions, including cirrhosis.No weight gain. Treating hypoglycemia: Use glucose tablets or gel, real fruit juice, or milk.
Miglitol blocks digestion of sucrose, so do not use table sugar, candy, soda pop, or Tang."
http://www.alaska.net/~akdm/clinical/meds/miglitol.htm
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