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Mixed Insulin

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MIXED INSULIN
(Humulin 50/50, Humulin 70/30, Novolin 70/30)


Instructions for Insulin: Mixed Dose:upstate.edu:"Wipe off the top of the bottle with an alcohol swab and turn the cloudy bottle on its side to roll between your hands. Pull plunger back to fill the syringe with ______units of air. Put needle through the top of the cloudy bottle, keeping bottle upright on table and push plunger down putting air into bottle. Take needle out empty. Pull plunger back to fill with ______units of air. Put needle through the top of the clear bottle. Keeping bottle upright on table, push plunger down. Leave needle in clear bottle and turn bottle upside down. Pull plunger halfway down to fill syringe with insulin. Check for air bubbles. If there are bubbles, push all the insulin back into the bottle. Pull plunger down again to ______units. When there are no bubbles, take needle out. Put needle through the top of cloudy bottle and turn it upside down. Pull plunger to________units. (_______R/H+______N/L/U). Take out needle. Check that you have the right number of units. If you pull up too much insulin, or if you see air bubbles, discard the insulin into the sink and go back to step 2"
http://www.upstate.edu/uhpated/diabetes/instruci.htm

This is how you prepare a mixed dose of insulin:lillydiabetes.com:"Your doctor may want you to take more than one type of insulin. There are two ways to do this: Use a premixed insulin, or mix the two types of insulin yourself. Both insulins can be put in the syringe at the same time, allowing you to take just one shot instead of two. "A units" reflects your doctor's recommendation for units of rapid-acting insulin. "B units" reflects your doctor's recommendation for units of longer-acting insulin."
http://www.lillydiabetes.com/Education/PreparingMixedDose.cfm

Pre-mixed insulin preparations:childhooddiabetes.com:"Pre-mixed insulin preparations are mixtures of short- and intermediate-acting insulins in a variety of ratios. Because of the changing needs in the ratios of the two types of insulin, the use of pre-mixed insulin preparations is not recommended by the International Society for Paediatric and Adolescent Diabetes (ISPAD). However, because using pre-mixed insulin means fewer daily insulin injections and the parents not having to mix insulin themselves, pre-mixed preparations are often used in the pre-pubertal period. Recent research has demonstrated that glycaemic control in pre-adolescent children on pre-mixed insulin was equivalent to children on a combination regimen."
http://www.childhooddiabetes.com/view.asp?documentID=74

Premixed insulin was preferred over patient-mixed insulin by elderly patients:hiru.mcmaster.ca:"BENEFITS: Preparation of a premixed insulin by elderly diabetic patients resulted in fewer errors and greater patient satisfaction compared with patient-mixed insulins, but metabolic control was not improved. ADVERSE EFFECTS: None detected. Background Metabolic control can be a problem in diabetic patients who take mixtures of short-acting and intermediate-acting insulin, particularly elderly patients because of their poorer eyesight and motor impairment. This study was done to determine the accuracy of elderly patients in mixing insulins and to assess the safety and efficacy of premixed insulins."
http://hiru.mcmaster.ca/dem/docs/provider/8000019.htm

For people who take a mixed-insulin twice each day :The Diabetes travel information website:"If you take a mixed insulin twice each day and are going on the same, west-to-east Saudi Arabia to Tokyo flight as above, you could do this: Discuss with your clinic staff about missing your second injection of mixed insulin and taking instead an injection of short-acting insulin supplied by the clinic. The dose will be about the same as the short-acting component of your usual mixture. You would then only be taking two main meals plus snacks on that day - but the day would be 5 1/2 hours shorter because of the time difference. If you are flying east-to-west, on the London to Mexico City flight, you could do this: Discuss with your clinic about taking your usual two injections per day plus an extra injection of short-acting insulin 8-10 hours after your first injection of the day. This would be just before the time of your usual third main meal. Take your next dose of mixed insulin with your fourth main meal. This way you will be taking four main meals plus snacks on that day, but the time difference will lengthen the day by 6 hours."
http://www.scottish-internet.co.uk/clients/diabetestravel/time_zones.htm

Facts about Insulin for 0-5 Year-olds:diabetesireland.ie:"Insulin is available in different types and combinations – short-acting, longer-acting and pre-mixed insulin. Small children are very sensitive to insulin, and the risk of low blood sugar is high. It is important not to be too strict in diabetes control. Pre-mixed insulins (e.g. Mixtard® - fixed combinations of short-acting and longer-acting insulin) Are often taken alone or in combination with other types of insulin divided into 2 - 3 injections per day. Are available in mixtures of 10/90; 20/80; 30/70; 40/60; 50/50. Mixtard® 20/80, for example, contains 20% Actrapid® and 80% Insulatard®. Vary in effect depending on the type of mixture. The more Actrapid® in the Mixtard®, the faster the effect."
http://www.diabetesireland.ie/view.asp?ID=318

Get to know your Insulin treatment better:my.diabetovalens.com:"Because of the changing needs in the ratios of the two types of insulin, the International Society does not recommend the use of pre-mixed insulin preparations for Paediatric and Adolescent Diabetes (ISPAD). However, because using pre-mixed insulin means fewer daily insulin injections and the parents not having to mix insulin themselves, pre-mixed preparations are often used in the pre-pubertal period. Recent research has demonstrated that glycaemic control in pre-adolescent children on pre-mixed insulin was equivalent to children on a combination regimen. In the adolescent group pre-mixed insulin was, however, associated with significantly poorer glycaemic control. Thus, pre-mixed insulins in a twice-daily injection regimen seem to be an excellent therapeutic approach in the pre-puberty years. Particularly as it is in this age group that needle-phobia is most prevalent"
http://my.diabetovalens.com/diab_kids/insulin.asp

Insulin formulation and species :d4pro.com:"Pre-mixed insulins (fixed ratio mixtures of soluble and isophane) are popular in some countries particularly for prepubertal children on twice-daily regimens. Although they reduce potential errors in drawing up insulin, they remove the flexibility offered by separate adjustment of the two types. Such flexibility is useful for children with variable food intake There is no clear evidence that pre-mixed insulins in young children are less effective, but there is some evidence of poorer metabolic control when they are used in adolescents Pre-mixed insulins with soluble:isophane in different ratios, e.g. 10:90, 15:85, 20:80, 25:75, 30:70, 40:60 and 50:50, are available in various countries from different manufacturers Pre-mixed insulins are most commonly used in pen injector devices Pre-mixed insulins may be useful when compliance (or adherence) to the regimen is a problem "
http://www.d4pro.com/diabetesguidelines/ispad/09_02.htm

:letstalkdiabetes.ca:"Diabetes control can be improved by using a mixture of short and intermediate-acting insulin. Certain ratios of short and immediate-acting insulin are available in pre-mixed formulations. The most common mixture is 30/70 insulin - 30% short-acting and 70% intermediate-acting (NPH) insulin. Most pre-mixed formulations begin their action after 1/2 hour, maintain a maximal effect for 4 to 8 hours, and their action usually ends after 24 hours. By eliminating the need for mixing insulin preparations, pre-mixed insulin may be a convenient alternative. A meal should follow within approximately 30 minutes of administration of the premixed insulin preparation. Remember: The actions of insulin vary in different individuals. Your doctor will help find the best insulin type and injection routine to suit your individual needs."
http://www.letstalkdiabetes.ca/e/view.asp?ID=289#premix

Is it OK to mix insulins together in the same syringe ahead of time? :lillydiabetes.com:"Follow your doctor's instructions on whether to mix your insulins ahead of time or just before giving your injection. Activity of the insulin mixture and storage requirements depend on the types of insulins mixed. Some insulins should not be mixed together in the same syringe. We recommend that prefilled syringes of either single formulations or mixtures of Humulin® (human insulin [rDNA origin]) be kept refrigerated and used within 21 days. Storage of prefilled syringes at room temperature is not recommended. There are no data on the stability and effectiveness of syringes prefilled with Humalog® (insulin lispro injection [rDNA origin]) alone or Humalog mixed with either Humulin® N (NPH human insulin [rDNA origin] isophane suspension), Humulin® L ( LENTE® human insulin [rDNA origin] zinc suspension), or Humulin® U (ULTRALENTE® human insulin [rDNA origin] extended zinc suspension)."
http://www.lillydiabetes.com/AskLilly/InsulinFAQ.cfm?NavProducts=1



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Last updated by Andrew Lopez, RN on Wednesday, September 29, 2010


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