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Tolbutamide (Orinase) additional uses, action/kinetics:nursespdr:"Action/Kinetics: Onset: 1 hr. t1/2: 4.5-6.5 hr. Time to peak levels: 3-4 hr. Duration: 6-12 hr. Changed in liver to inactive metabolites. Excreted through the kidneys. Additional Uses: Most useful for clients with poor general physical status who should receive a short-acting compound. Tolbutamide sodium is used to diagnose pancreatic islet cell tumors. It causes blood glucose, in the presence of a tumor, to drop quickly after IV administration and remain low for 3 hr." http://www.nursespdr.com/members/database/ndrhtml/tolbutamide.html Tolbutamide (Orinase) why is it prescribed?:medlineplus:"Tolbutamide is used to treat type II (noninsulin-dependent) diabetes (formerly 'adult-onset'), particularly in people whose diabetes cannot be controlled by diet alone. Tolbutamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must produce insulin for this drug to work. Tolbutamide is not used to treat type I (insulin-dependent) diabetes (formerly 'juvenile-onset'). This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information" http://www.nlm.nih.gov/medlineplus/druginfo/medmaster/a682481.html Tolbutamide (Orinase) who shouldn't take it?:health.msn.com:"Before taking tolbutamide, tell your doctor if you have kidney disease; have liver disease; have thyroid disease; have Type 1 diabetes mellitus (insulin-dependent diabetes); have a serious infection, illness, or injury; or need surgery. You may not be able to take tolbutamide, or you may require a dosage adjustment or special monitoring during treatment if you have any of the conditions listed above. Tolbutamide is in the FDA pregnancy category D. This means that tolbutamide is known to be harmful to an unborn baby. Insulin is usually the drug of choice for controlling diabetes during pregnancy. Do not take tolbutamide without first talking to your doctor if you are pregnant or could become pregnant during treatment. Tolbutamide passes into breast milk and may cause hypoglycemia (low blood sugar) in a nursing baby. Do not take tolbutamide without first talking to your doctor if you are breast-feeding a baby" http://content.health.msn.com/drug_article/article/4046.2105?bn=Orinase#nottake Side effects of Tolbutamide (Orinase):healthsquare.com:"Side effects from Orinase are rare and seldom require discontinuation of the medication. More common side effects may include: Bloating, heartburn, nausea Less common or rare side effects may include: Anemia and other blood disorders, blistering, changes in taste, headache, hepatic porphyria (a condition frequently characterized by sensitivity to light, stomach pain, and nerve damage, caused by excessive levels of a substance called porphyrin in the liver), hives, itching, redness of the skin, skin eruptions, skin rash Orinase, like all oral antidiabetics, may cause hypoglycemia (low blood sugar). The risk of hypoglycemia can be increased by missed meals, alcohol, other medications, fever, trauma, infection, surgery, or excessive exercise. To avoid hypoglycemia, you should closely follow the dietary and exercise plan suggested by your physician." http://www.healthsquare.com/newrx/ori1312.htm What are the precautions when taking Tolbutamide (Orinase):healthtrust.com:"Wear disease medical alert identification for diabetes. If you are 80 years of age or older, you may be more sensitive to low blood sugars. Keep hard candies, liquid glucose, or milk on hand for low blood sugars. Do not drive if blood sugar has been low. There is a greater risk of an accident. Avoid alcohol intake (includes wine, beer, and liquor). Tell healthcare provider if you are allergic to any medicine. Make sure to tell about the allergy and how it affected you. This includes telling about rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, throat; or any other symptoms involved. Tell healthcare provider if you are pregnant or plan on getting pregnant. Tell healthcare provider if you are breast-feeding." http://www.healthtrust.com/intmed/Access2Cons2/ConsDrugs/Tolbutamidecd.shtml Tolbutamide (Orinase) advanced consumer information:drugs.com:"For oral dosage form (tablets): For treating type 2 diabetes: Adults—At first, 1000 to 2000 milligrams (mg) a day. Some elderly people may need lower doses to start. The dose is usually divided into two doses. These doses are taken before the morning and evening meals. Your doctor may change your dose a little at a time if needed. The dose is usually not more than 3000 mg a day. Children—The type of diabetes treated with this medicine is rare in children. However, if a child needs this medicine, the dose would have to be determined by the doctor" http://www.drugs.com/xq/cfm/pageID_0/htm_202742/type_cons/bn_Orinase/micr_medex/qx/index.htm Tolbutamide (Orinase) who is it for?:drugdigest:"Tolbutamide is used to treat type II (noninsulin-dependent) diabetes (formerly "adult-onset"), particularly in people whose diabetes cannot be controlled by diet alone. Tolbutamide lowers blood sugar by stimulating the pancreas to secrete insulin and helping the body use insulin efficiently. The pancreas must produce insulin for this drug to work. Tolbutamide is not used to treat type I (insulin-dependent) diabetes (formerly "juvenile-onset"). This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information." http://www.drugdigest.org/DD/DVH/Uses/0,3915,667|Orinase,00.html Tolbutamide (Orinase) what should you monitor?:usadrug.com:"Check blood sugar as ordered by healthcare provider. Call if glucose is less than 80 mg/dL or if greater than 250 mg/dL. Bring results to follow-up visits. Watch for low blood sugar. This can cause anger, shaking, rapid heartbeats, confusion, sweating. Watch for high blood sugar. Causes many trips to the bathroom, thirst, and weight loss. Check blood work. Talk with healthcare provider. Follow diet plan and exercise program as recommended by healthcare provider. Have a yearly eye exam and visit to the foot doctor" http://www.usadrug.com/IMCAccess/ConsDrugs/Tolbutamidecd.shtml#Monitor Tolbutamide (Orinase) drug interactions:ElizJack@IntNet.Net:"Inform your doctor about all the medicines you use (both prescription and nonprescription) especially if you are using "blood thinners" (Coumadin-like drugs), MAO inhibitors (e.g., furazolidone, phenelzine, selegiline, tranylcypromine), beta blockers (e.g., metoprolol, propranolol, timolol) including certain glaucoma eye medicines, aspirin-like drugs or probenecid because your dose may need to be adjusted." http://members.aol.com/lowcarbs/diabetes/meds/tolb.htm Search Nursing Diabetics http://www.nursingdiabetics.com/A-Z_list/ ******************************************************
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